人类和啮齿动物中的肝祖细胞——多种途径，多种候选细胞
Hepatocyte progenitors in man and in rodents--multiple pathways, multiple candidates.
作者信息
Laurson Joanna, Selden Clare, Hodgson Humphrey J F
机构信息
Centre for Hepatology, Royal Free and University College Medical School, Hampstead, London, UK.
出版信息
Int J Exp Pathol. 2005 Feb;86(1):1-18. doi: 10.1111/j.0959-9673.2005.00410.x.
Abstract
In severe injury, liver-cell progenitors may play a role in recovery, proliferating, and subsequently differentiating into mature liver cells. Identifying these progenitors has major therapeutic potential for ex vivo pharmaceutical testing, bioartificial liver support, tissue engineering and gene therapy protocols. Potential liver-cell progenitors have been identified from bone marrow, peripheral blood, cord blood, foetal liver, adult liver and embryonic stem cells. Differences and similarities are found among cells isolated from rodents and humans. This review will discuss identifying markers and differentiation potential in in vitro and in vivo models of these putative progenitors in both humans and rodents.
摘要
在严重损伤时，肝细胞祖细胞可能在恢复过程中发挥作用，进行增殖，随后分化为成熟肝细胞。识别这些祖细胞对于体外药物测试、生物人工肝支持、组织工程和基因治疗方案具有重大治疗潜力。已从骨髓、外周血、脐带血、胎儿肝脏、成人肝脏和胚胎干细胞中鉴定出潜在的肝细胞祖细胞。在从啮齿动物和人类分离出的细胞之间发现了差异和相似之处。本综述将讨论在人类和啮齿动物中这些假定祖细胞的体外和体内模型中的识别标志物和分化潜能。
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