Jaehne M, Dippel A, Sagowski C
Klinik und Poliklinik für Hals-, Nasen- und Ohrenheilkunde, Universitätsklinikum Hamburg-Eppendorf.
HNO. 2005 Nov;53(11):940-4. doi: 10.1007/s00106-004-1204-z.
Salivary duct carcinoma (SDC) is a rare adenocarcinoma of the salivary glands which usually occurs in the parotid gland (approx. 80%), but is also found in the submandibular gland (approx. 12%) and the minor salivary glands. Due to the low incidence of this tumour-particularly in terms of involvement of the submandibular and minor salivary glands-only limited clinical data is available.
PATIENTS/METHOD: In a retrospective investigation, follow-ups of six patients with a SDC of the submandibular gland were analysed and the surgical measures evaluated for their efficiency.
At the time of diagnosis, varying tumor stages were present (2xT1, 3xT2, 1xT1). Initial lymph node metastasis was observed in four (66.6%) of the six patients. In all patients, the submandibular gland was resected and neck dissection performed, in two cases (33,3%) this was followed by radiotherapy. Four patients developed a life-threatening local recurrence. Only one patient developed distant metastasis. Two thirds of the patients died due to tumor-related disease after an average of 35.5 months.
The clinical course of patients with SDC of the submandibular gland exhibits a high (66.6%) rate of local recurrence, crucial for the following clinical course. The treatment of these patients, therefore, must include radical tumor resection as well as tissue resection with a wide margin.
涎腺导管癌（SDC）是一种罕见的涎腺癌，通常发生于腮腺（约80%），但也可见于下颌下腺（约12%）和小涎腺。由于该肿瘤发病率低，尤其是累及下颌下腺和小涎腺的情况，仅有有限的临床数据。
患者/方法：在一项回顾性研究中，分析了6例下颌下腺涎腺导管癌患者的随访情况，并评估了手术措施的有效性。
诊断时，存在不同的肿瘤分期（2例T1期，3例T2期，1例T1期）。6例患者中有4例（66.6%）观察到初始淋巴结转移。所有患者均切除了下颌下腺并进行了颈部清扫，2例（33.3%）术后接受了放疗。4例患者出现危及生命的局部复发。仅1例患者发生远处转移。三分之二的患者在平均35.5个月后因肿瘤相关疾病死亡。
下颌下腺涎腺导管癌患者的临床病程显示出较高的局部复发率（66.6%），这对后续临床病程至关重要。因此，这些患者的治疗必须包括根治性肿瘤切除以及广泛切缘的组织切除。
