涎腺导管癌：临床特征与治疗策略
Salivary duct carcinoma: clinical characteristics and treatment strategies.
作者信息
Guzzo M, Di Palma S, Grandi C, Molinari R
机构信息
Maxillo-Facial Surgery and Otolaryngology, Instituto Nazionale Tumori, Milan, Italy.
出版信息
Head Neck. 1997 Mar;19(2):126-33. doi: 10.1002/(sici)1097-0347(199703)19:2<126::aid-hed7>3.0.co;2-6.
BACKGROUND
Salivary duct carcinoma (SDC) is a highly malignant tumor of the salivary gland.
METHODS
Twenty-six cases observed during the period 1975 to 1994 were selected from the pathology archives of the Instituto Nazionale Tumori of Milan. A review of all the similar cases published in the literature and comparison with the present series was performed.
RESULTS
SDC was mainly a parotid gland tumor diagnosed at an advanced stage. Lymphatic involvement seems to be related to T stage. Distant spread was evidently related to the presence of lymph node metastasis. Surgery with radiotherapy was the standard treatment. The only demonstrable negative prognostic factor was the presence of node metastases (p = 0.01).
CONCLUSIONS
Most patients died of disseminated disease in spite of an aggressive and often successful local-regional treatment. The role of a prophylactic ipsilateral neck dissection and adjunctive systemic treatment should be investigated.
背景
涎腺导管癌（SDC）是涎腺的一种高度恶性肿瘤。
方法
从米兰国家肿瘤研究所的病理档案中选取了1975年至1994年间观察的26例病例。对文献中所有类似病例进行了回顾，并与本系列病例进行了比较。
结果
SDC主要是一种腮腺肿瘤，在晚期被诊断出来。淋巴受累似乎与T分期有关。远处转移显然与淋巴结转移的存在有关。手术加放疗是标准治疗方法。唯一可证实的负面预后因素是存在淋巴结转移（p = 0.01）。
结论
尽管进行了积极且往往成功的局部区域治疗，但大多数患者死于播散性疾病。应研究预防性同侧颈清扫术和辅助全身治疗的作用。
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