Jones Bradley W
Department of Biology, The University of Mississippi, 122 Shoemaker Hall, University, MS 38677, USA.
Dev Biol. 2005 Feb 15;278(2):265-73. doi: 10.1016/j.ydbio.2004.11.022.
Neurons and glia are generated from multipotent neural progenitors. In Drosophila, the transcriptional regulation of glial vs. neuronal fates is controlled by the expression of the transcription factor encoded by the glial cells missing gene (gcm) in multiple neural lineages. The cis-regulatory control of gcm transcription serves as a nodal point to translate a complex array of spatially and temporally regulated transcription factors in distinct neural lineages into glial-specific expression. Gcm acts synergistically with several downstream transcription factors to initiate and maintain glial-specific gene expression. The identification of a large set of glial-specific genes through the application of computational and whole genome tools provides the opportunity to analyze the transcriptional regulation of glial cell development at the genomic level in a relatively simple genetic model system.
神经元和神经胶质细胞由多能神经祖细胞产生。在果蝇中，神经胶质细胞与神经元命运的转录调控由多个神经谱系中胶质细胞缺失基因（gcm）编码的转录因子的表达所控制。gcm转录的顺式调控作为一个节点，将不同神经谱系中一系列复杂的时空调控转录因子转化为胶质细胞特异性表达。Gcm与几种下游转录因子协同作用，启动并维持胶质细胞特异性基因表达。通过应用计算和全基因组工具鉴定出大量胶质细胞特异性基因，这为在相对简单的遗传模型系统中从基因组水平分析胶质细胞发育的转录调控提供了机会。
