Goi R, Matsuda M, Maekawa H, Ogawa T, Sakata S
Third Department of Internal Medicine, Gifu University School of Medicine, Japan.
Intern Med. 1992 Jan;31(1):64-8. doi: 10.2169/internalmedicine.31.64.
Two cases of Hashimoto's thyroiditis are presented: a woman who suffered twice from transient hypothyroidism (Case 1), and a woman with polycystic ovary syndrome who had transient hypothyroidism which was inferred to have been caused by exacerbation of Hashimoto's disease (Case 2). In both cases, fluctuation in titers of both anti-thyroglobulin (TGHA) and antimicrosomal antibodies (MCHA) was observed. Although an increased serum thyroid stimulating hormone (TSH) concentration in Case 2 was associated with the increased titer of MCHA, this was not true of Case 1. Measurement of serum iodine concentration in Case 1 disclosed no correlation between serum TSH and iodine concentrations, suggesting that episodes of hypothyroidism in this patient are not due to iodine-induced hypothyroidism. The transient hypothyroidism in Case 2 was considered to be due to fluctuations in immune mechanism(s), but the reason in Case 1 was not clear in the present study.
一名女性曾两次出现短暂性甲状腺功能减退（病例1），另一名患有多囊卵巢综合征的女性出现短暂性甲状腺功能减退，据推测是由桥本氏病加重所致（病例2）。在这两个病例中，均观察到抗甲状腺球蛋白（TGHA）和抗微粒体抗体（MCHA）滴度的波动。虽然病例2中血清促甲状腺激素（TSH）浓度升高与MCHA滴度升高有关，但病例1并非如此。病例1中血清碘浓度的测量显示血清TSH与碘浓度之间无相关性，表明该患者的甲状腺功能减退发作并非由碘诱导的甲状腺功能减退所致。病例2中的短暂性甲状腺功能减退被认为是由于免疫机制的波动，但在本研究中病例1的原因尚不清楚。
