Ochman Howard, Daubin Vincent, Lerat Emmanuelle
Department of Biochemistry and Molecular Biophysics, University of Arizona, Tucson, AZ 87521, USA.
Trends Genet. 2005 Jan;21(1):1-3. doi: 10.1016/j.tig.2004.11.006.
The resolution of the complete sequences of several hemiascomycete genomes provides new insights into the ways that yeast genomes change in size and in gene contents. These genomes provide evidence of whole-genome duplication occurring before the divergence of Saccharomyces cerevisiae and Candida glabrata, followed by massive gene loss that restored diploidy. The pattern of genome evolution in yeast differs from that in bacteria apparently as a result of stronger selective constraints on bacterial chromosomes.
几种半子囊菌基因组完整序列的解析为酵母基因组在大小和基因含量方面发生变化的方式提供了新的见解。这些基因组证明了在酿酒酵母和光滑念珠菌分化之前发生了全基因组复制，随后是大量基因丢失，从而恢复了二倍体状态。酵母基因组的进化模式明显不同于细菌，这显然是由于对细菌染色体有更强的选择限制。
