Raffa Robert B, Desai Prarthna
Department of Pharmaceutical Sciences, Temple University School of Pharmacy, 3307 N. Broad Street, Philadelphia, PA 19140, USA.
Brain Res. 2005 Jan 25;1032(1-2):200-2. doi: 10.1016/j.brainres.2004.10.052.
Previous work provided indirect evidence that planarians undergo abstinence-induced withdrawal from cocaine. The present study's purpose was to determine if planarians display withdrawal signs and, if so, to quantify the behaviors. Planarians were soaked in cocaine then transferred to either the same cocaine concentration or cocaine-free water. Compared to the cocaine/cocaine group, the cocaine/water group displayed a significant number of atypical behaviors, providing direct evidence of a 'withdrawal phenomenon' in planarians.
先前的研究提供了间接证据，表明涡虫会经历因戒断可卡因而产生的戒断反应。本研究的目的是确定涡虫是否会表现出戒断症状，如果是，则对这些行为进行量化。将涡虫浸泡在可卡因中，然后转移到相同浓度的可卡因溶液或无可卡因的水中。与可卡因/可卡因组相比，可卡因/水组表现出大量异常行为，为涡虫的“戒断现象”提供了直接证据。
