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小白菊内酯可抑制涡虫中可卡因诱导的戒断行为的表达。

Parthenolide prevents the expression of cocaine-induced withdrawal behavior in planarians.

作者信息

Rowlands Amanda L, Pagán Oné R

机构信息

Department of Biology, West Chester University, West Chester, PA 19383-2112, USA.

出版信息

Eur J Pharmacol. 2008 Mar 31;583(1):170-2. doi: 10.1016/j.ejphar.2008.01.012. Epub 2008 Jan 26.

DOI:10.1016/j.ejphar.2008.01.012
PMID:18275955
Abstract

We recently reported that parthenolide and related sesquiterpene lactones are able to prevent and reverse behavioral responses in planarian worms induced by acute cocaine exposure. Previous reports indicate that when planarians are chronically exposed to microM concentrations of cocaine, they display stereotypical withdrawal-like behaviors when the cocaine is removed. Here we report that parthenolide prevents this cocaine-induced expression of planarian withdrawal-like behaviors.

摘要

我们最近报道，小白菊内酯及相关倍半萜内酯能够预防和逆转急性可卡因暴露诱导的涡虫行为反应。先前的报道表明，当涡虫长期暴露于微摩尔浓度的可卡因时，去除可卡因后它们会表现出刻板的戒断样行为。在此我们报道，小白菊内酯可预防这种可卡因诱导的涡虫戒断样行为的表达。

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