Conaway Joan Weliky, Florens Laurence, Sato Shigeo, Tomomori-Sato Chieri, Parmely Tari J, Yao Tingting, Swanson Selene K, Banks Charles A S, Washburn Michael P, Conaway Ronald C
Stowers Institute for Medical Research, Kansas City, MO 64110, USA.
FEBS Lett. 2005 Feb 7;579(4):904-8. doi: 10.1016/j.febslet.2004.11.031.
The multiprotein Mediator (Med) complex is an evolutionarily conserved transcriptional regulator that plays important roles in activation and repression of RNA polymerase II transcription. Prior studies identified a set of more than twenty distinct polypeptides that compose the Saccharomyces cerevisiae Mediator. Here we discuss efforts to characterize the subunit composition and associated activities of the mammalian Med complex.
多蛋白中介体（Med）复合物是一种在进化上保守的转录调节因子，在RNA聚合酶II转录的激活和抑制中发挥重要作用。先前的研究鉴定出一组二十多种不同的多肽，它们构成了酿酒酵母中介体。在这里，我们讨论了对哺乳动物Med复合物的亚基组成和相关活性进行表征的工作。
