Meĭren D V, Urbanovich E L, Sniedze T N, Khagi Kh B, Gilev A P
Biull Eksp Biol Med. 1977 Feb;83(2):162-4.
N1-(3'-Butyrolactono)-5-fluorouracil, N1-(2'-furanidyl) 5-trifluoromethyluracil, N1-(2'-furanidyl)-5-fluoracil are split in the rat organism with the formation of free 5-fluorouracil. The destruction of the C--N bonds in the molecule of the N1-(2'-furanidyl)-5-fluoracil takes place in the liver microsomes. This process is strengthened by NADPH and weakened by SKF-525A. All the three furanidylpyrimidines studied induced differential spectra of type I in the suspension of the liver microsomes. This fact testifies to the interaction of these substances with the cytochrome P-450.
N1-(3'-丁内酯基)-5-氟尿嘧啶、N1-(2'-呋喃基)-5-三氟甲基尿嘧啶、N1-(2'-呋喃基)-5-氟尿嘧啶在大鼠体内分解，生成游离的5-氟尿嘧啶。N1-(2'-呋喃基)-5-氟尿嘧啶分子中的C-N键在肝脏微粒体中发生断裂。此过程因NADPH而增强，因SKF-525A而减弱。所研究的三种呋喃基嘧啶在肝脏微粒体悬液中均诱导出I型差异光谱。这一事实证明这些物质与细胞色素P-450发生了相互作用。
