Pilz Julia Beatrice, Wernsdorfer Gunther, Sirichaisinthop Jeeraphat, Rojanawatsirivet Chaiporn, Wiedermann Gerhard, Wernsdorfer Walther H
Institute of Microbiology, Humboldt-University, Berlin, Germany.
Wien Klin Wochenschr. 2004;116 Suppl 4:41-6.
Lumefantrine (benflumetol) belongs to the class-2 blood schizontocidal compounds. In combination with artemether it serves as an alternative drug for treating chloroquine-resistant infections with Plasmodium falciparum. In view of activity correlations with mefloquine, it is important to monitor the parasite's intrinsic sensitivity to lumefantrine in areas with multi-drug resistant P. falciparum, the objective of this study. The observations were carried out in 2002 at Mae Sot, northwestern Thailand, near the border to Myanmar. The 41 successfully in-vitro tested parasite isolates yielded a geometric mean cut-off concentration of schizont maturation of 237.54 nM, and EC50, EC90 and EC90 values of 15.13 nM, 86.71 nM and 359.97 nM, respectively. As compared to the findings of 1998 and 1999, the susceptibility to lumefantrine has increased, possibly due to the improved therapeutic response of mefloquine-resistant P. falciparum infections to combined treatment with artesunate + mefloquine. The EC9o and EC99 data of 2002 for lumefantrine in the study area suggest fully curative clinical-parasitological efficacy.
卤泛群（本芴醇）属于2类血液裂殖体杀灭化合物。它与蒿甲醚联合使用，可作为治疗耐氯喹恶性疟原虫感染的替代药物。鉴于其与甲氟喹的活性相关性，在多药耐药恶性疟原虫流行地区监测寄生虫对卤泛群的内在敏感性很重要，这也是本研究的目的。观察于2002年在泰国西北部靠近缅甸边境的湄索进行。41株成功进行体外测试的寄生虫分离株产生的裂殖体成熟几何平均截止浓度为237.54 nM，EC50、EC90和EC99值分别为15.13 nM、86.71 nM和359.97 nM。与1998年和1999年的研究结果相比，对卤泛群的敏感性有所增加，这可能是由于耐甲氟喹恶性疟原虫感染对青蒿琥酯+甲氟喹联合治疗的治疗反应有所改善。2002年该研究区域卤泛群的EC90和EC99数据表明其具有完全治愈的临床寄生虫学疗效。
