通过关环复分解反应实现巴比妥酸衍生物及其类似物的螺环化
Spiro-annulation of barbituric acid derivatives and its analogs by ring-closing metathesis reaction.
作者信息
Kotha Sambasivarao, Deb Ashoke Chandra, Kumar Ramanatham Vinod
机构信息
Department of Chemistry, Indian Institute of Technology-Bombay, Powai, Mumbai 400076, India.
出版信息
Bioorg Med Chem Lett. 2005 Feb 15;15(4):1039-43. doi: 10.1016/j.bmcl.2004.12.034.
PMID:15686908
Abstract
Barbituric acid 1 and related beta-dicarbonyl compounds were dialkenylated under the phase-transfer catalyst [e.g., benzyltriethylammonium chloride (BTEAC)] conditions to generate the diallylated products. These diallylated products were subjected to the ring-closing metathesis (RCM) reaction to deliver the corresponding spiro-annulated derivatives.
摘要
巴比妥酸1及相关的β-二羰基化合物在相转移催化剂[例如苄基三乙基氯化铵（BTEAC）]条件下进行二烯基化反应，生成二烯丙基化产物。这些二烯丙基化产物进行关环复分解（RCM）反应，得到相应的螺环化衍生物。
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