含巴比妥酸部分的螺环核苷的合成与性质
Synthesis and properties of spiro nucleosides containing the barbituric acid moiety.
作者信息
Renard Annabelle, Lhomme Jean, Kotera Mitsuharu
机构信息
Chimie Bioorganique, L.E.D.S.S., Associé au CNRS, Université Joseph Fourier, BP 53, 38041 Grenoble Cedex 9, France.
出版信息
J Org Chem. 2002 Feb 22;67(4):1302-7. doi: 10.1021/jo016194y.
PMID:11846678
Abstract
The two chiral spiro nucleosides 4 and 5 containing the barbituric acid moiety were efficiently synthesized from optically pure precursors, and their properties were studied. The carbocyclic nucleoside 5 is considerably more stable against ring opening than the deoxyribosyl derivative 4. Both compounds present enhanced hydrogen bonding capacity with diacetyladenosine.
摘要
由光学纯的前体高效合成了两种含有巴比妥酸部分的手性螺核苷4和5，并对它们的性质进行了研究。碳环核苷5比脱氧核糖基衍生物4对开环具有更高的稳定性。两种化合物与二乙酰腺苷都具有增强的氢键结合能力。
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