在水相二乙胺介质中，通过更绿色、更高效的方法实现巴比妥酸与硝基烯烃的迈克尔加成反应。
A greener, efficient approach to Michael addition of barbituric acid to nitroalkene in aqueous diethylamine medium.
机构信息
Department of Chemistry, College of Science, King Saud University, P. O. Box 2455, Riyadh 11451, Saudi Arabia.
出版信息
Molecules. 2014 Jan 17;19(1):1150-62. doi: 10.3390/molecules19011150.
An efficient method for the synthesis of a variety of pyrimidine derivatives 3a-t by reaction of barbituric acids 1a,b as Michael donor with nitroalkenes 2a-k as Michael acceptor using an aqueous medium and diethylamine is described. This 1,4-addition strategy offers several advantages, such as using an economic and environmentally benign reaction media, high yields, versatility, and shorter reaction times. The synthesized compounds were identified by 1H-NMR, 13C-NMR, CHN, IR, and MS. The structure of compound 3a was further confirmed by single crystal X-ray structure determination.
本文描述了一种在水介质和二乙胺存在下，通过巴比妥酸 1a,b 作为迈克尔供体与硝基烯烃 2a-k 作为迈克尔受体反应，高效合成多种嘧啶衍生物 3a-t 的方法。这种 1,4-加成策略具有许多优点，例如使用经济且环境友好的反应介质、高收率、多功能性和较短的反应时间。合成的化合物通过 1H-NMR、13C-NMR、CHN、IR 和 MS 进行了鉴定。化合物 3a 的结构进一步通过单晶 X 射线结构确定得到了证实。
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