Wang Guan-Wu, Gao Jie
Hefei National Laboratory for Physical Sciences at Microscale and Department of Chemistry,University of Science and Technology of China, Hefei, Anhui 230026, PR China.
Org Lett. 2009 Jun 4;11(11):2385-8. doi: 10.1021/ol900451d.
An efficient methodology for the oxidative addition reaction of various aldehydes with 5,5-dimethylcyclohexane-1,3-dione and 1,3-indandione to selectively afford spiro dihydrofuran and cyclopropane derivatives, promoted by molecular iodine and dimethylaminopyridine under mechanical milling conditions, has been demonstrated. The products were obtained in good to excellent yields. A possible mechanism of this unusual reaction process is proposed.
已证明一种有效的方法，即在机械研磨条件下，由分子碘和二甲基氨基吡啶促进，使各种醛与5,5 - 二甲基环己烷 - 1,3 - 二酮和1,3 - 茚二酮发生氧化加成反应，以选择性地得到螺二氢呋喃和环丙烷衍生物。产物的产率良好至优异。还提出了这种不寻常反应过程的可能机理。
