高血清晚期糖基化终产物水平预示非糖尿病女性冠心病死亡率增加，但非糖尿病男性并非如此：一项基于人群的18年随访研究。

High serum levels of advanced glycation end products predict increased coronary heart disease mortality in nondiabetic women but not in nondiabetic men: a population-based 18-year follow-up study.

作者信息

Kilhovd Bente K, Juutilainen Auni, Lehto Seppo, Rönnemaa Tapani, Torjesen Peter A, Birkeland Kåre I, Berg Tore J, Hanssen Kristian F, Laakso Markku

机构信息

Diabetes Research Centre, Department of Medicine, Aker University Hospital, Oslo, Finland.

出版信息

Arterioscler Thromb Vasc Biol. 2005 Apr;25(4):815-20. doi: 10.1161/01.ATV.0000158380.44231.fe. Epub 2005 Feb 3.

DOI:10.1161/01.ATV.0000158380.44231.fe

PMID:15692098

Abstract

BACKGROUND

Advanced glycation end products (AGEs), modification products of glycation or glycoxidation of proteins and lipids, have been linked to premature atherosclerosis in patients with diabetes as well as in nondiabetic subjects.

METHODS AND RESULTS

Serum levels of AGEs were measured with an immunoassay in samples obtained at baseline examination of a random sample of 1141 nondiabetic individuals (535 men and 606 women), aged 45 to 64 years, living in Kuopio, East Finland, or Turku, West Finland in 1982 to 1984. After 18 years of follow-up, all-cause mortality, cardiovascular disease (CVD), and coronary heart disease (CHD) mortality were registered on the basis of copies of death certificates. Multivariate Cox regression model showed a significant association of serum AGEs with all-cause (P=0.012), CVD (P=0.018), and CHD (P=0.008) mortality in women but not in men. Fasting serum AGEs in the highest quartile were an independent risk factor for all-cause (hazards ratio [HR], 1.90; 95% CI, 1.16 to 3.11; P=0.011) and CHD (HR, 6.51; 95% CI, 1.78 to 23.79; P=0.005) mortality in women, even after the adjustment for confounding factors, including highly sensitive C-reactive protein.

CONCLUSIONS

The present study is the first to show that serum levels of AGEs can predict total, CVD, and CHD mortality in nondiabetic women.

摘要

背景

晚期糖基化终末产物（AGEs）是蛋白质和脂质糖基化或糖氧化的修饰产物，已被证实与糖尿病患者以及非糖尿病个体的动脉粥样硬化提前发生有关。

方法与结果

采用免疫分析法测量了1982年至1984年间居住在芬兰东部库奥皮奥或芬兰西部图尔库、年龄在45至64岁之间的1141名非糖尿病个体（535名男性和606名女性）随机样本基线检查时采集的样本中的血清AGEs水平。经过18年的随访，根据死亡证明副本记录全因死亡率、心血管疾病（CVD）和冠心病（CHD）死亡率。多变量Cox回归模型显示，血清AGEs与女性的全因死亡率（P = 0.012）、CVD死亡率（P = 0.018）和CHD死亡率（P = 0.008）显著相关，而与男性无关。即使在对包括高敏C反应蛋白在内的混杂因素进行调整后，最高四分位数的空腹血清AGEs仍是女性全因死亡率（风险比[HR]，1.90；95%可信区间[CI]，1.16至3.11；P = 0.011）和CHD死亡率（HR，6.51；95%CI，1.78至23.79；P = 0.005）的独立危险因素。