Rigotti A
Departamento de Gastroenterología, Facultad de Medicina, Pontificia Universidad Católica, Santiago, Chile.
Biol Res. 2000;33(2):97-103. doi: 10.4067/s0716-97602000000200009.
Scavenger receptors were discovered as cell surface proteins capable of binding and internalization of modified lipoproteins. These receptors exhibit a broad ligand binding specificity including potential physiological and pathophysiological ligands other than modified lipoproteins. Different classes of scavenger receptors have been identified, and their relevance in normal and pathological conditions is under investigation. Recent in vitro and in vivo studies strongly support the role of class A and class B scavenger receptors in lipid transport and atherogenesis.
清道夫受体最初被发现是一类能够结合并内化修饰脂蛋白的细胞表面蛋白。这些受体具有广泛的配体结合特异性，除了修饰脂蛋白外，还包括潜在的生理和病理生理配体。现已鉴定出不同类别的清道夫受体，它们在正常和病理条件下的相关性正在研究中。最近的体外和体内研究有力地支持了A类和B类清道夫受体在脂质转运和动脉粥样硬化形成中的作用。
