Greaves D R, Gough P J, Gordon S
Sir William Dunn School of Pathology, University of Oxford, UK.
Curr Opin Lipidol. 1998 Oct;9(5):425-32. doi: 10.1097/00041433-199810000-00006.
Scavenger receptors bind and internalize modified lipoproteins. There are several different classes of scavenger receptors in mammalian cells and their relative contribution to lipid transport in normal physiology and pathological conditions such as atherosclerosis has been the subject of intense investigation. Mice with a disruption in the macrophage scavenger receptor SR-A gene exhibit a reduced size of atherosclerotic lesions and also exhibit an enhanced susceptibility to pathogens and endotoxic shock. In addition to their role in lipid transport, scavenger receptors play important roles in host defence and in the regulation of acquired immunity. Recent progress in delineating the mechanisms by which oxidized LDL effects changes in gene expression will be reviewed.
清道夫受体可结合并内化修饰的脂蛋白。哺乳动物细胞中有几种不同类型的清道夫受体，它们在正常生理以及动脉粥样硬化等病理状况下对脂质转运的相对贡献一直是深入研究的主题。巨噬细胞清道夫受体SR-A基因缺失的小鼠表现出动脉粥样硬化病变尺寸减小，并且对病原体和内毒素休克的易感性增强。除了在脂质转运中的作用外，清道夫受体在宿主防御和获得性免疫调节中也发挥着重要作用。本文将综述在阐明氧化型低密度脂蛋白影响基因表达变化机制方面的最新进展。
