Kos-Kudla B, Ostrowska Z, Marek B, Kajdaniuk D, Nowak M, Kudla M, Glogowska-Szelag J, Lisik V
Dept. of Pathophysiology and Endocrinology, Silesian Medical University, Zabrze.
Endocr Regul. 2004 Sep;38(3):111-8.
of this study was to assess daily rhythm of androstendione (delta4alpha) and free testosterone (FT) levels in postmenopausal asthmatic women before and after hormonal replacement therapy and the influence of inhaled glucocorticosteroids (GC).
54 asthmatic and 20 healthy postmenopausal women (aged 48-59) before and after 6 months of estrogen plus progestin therapy (EPT) were studied. Hormone concentrations in serum (delta4alpha and FT) were assessed with the use of RIA method. Statistical analysis of the circadian rhythm was performed with the use of cosinor test according to Halberg et al
Cosinor analysis of delta4alpha and FT secretion during the day showed existence of daily rhythm in three studied groups before as well as after postmenopausal hormone therapy (HT). A statistically significant decrease of circadian concentrations of delta4alpha and FT in groups of patients treated with GC was observed. Changes in amplitude of delta4alpha and FT rhythm between studied groups were not observed. However, displacement of rhythm acrophase of studied hormones in asthmatic women in comparison to control group before and after HT was shown. No significant differences in circadian values of delta4alpha and FT concentrations before HT use compared to values after HT were shown.
Postmenopausal asthmatic women show diminished circadian concentrations of androstendione and free testosterone in serum caused among other things by inhalative GC. Postmenopausal hormone therapy did not influence any changes in function of studied endocrine organs.
本研究旨在评估绝经后哮喘女性在激素替代治疗前后雄烯二酮（δ4α）和游离睾酮（FT）水平的每日节律以及吸入糖皮质激素（GC）的影响。
对54名哮喘绝经后女性和20名健康绝经后女性（年龄48 - 59岁）在接受雌激素加孕激素治疗（EPT）6个月前后进行研究。采用放射免疫分析法（RIA）评估血清中的激素浓度（δ4α和FT）。根据哈尔伯格等人的方法，使用余弦分析对昼夜节律进行统计分析。
对δ4α和FT白天分泌情况的余弦分析表明，在绝经后激素治疗（HT）前后，三个研究组中均存在每日节律。观察到接受GC治疗的患者组中，δ4α和FT的昼夜浓度有统计学意义的下降。未观察到研究组之间δ4α和FT节律幅度的变化。然而，显示出哮喘女性与对照组相比，在HT前后研究激素的节律峰相位发生了位移。未显示出HT使用前与HT后δ4α和FT浓度的昼夜值有显著差异。
绝经后哮喘女性血清中雄烯二酮和游离睾酮的昼夜浓度降低，部分原因是吸入性GC。绝经后激素治疗未影响所研究内分泌器官功能的任何变化。
