Kos-Kudla B, Ostrowska Z, Marek B, Ciesielska-Kopacz N, Kudla M, Kajdaniuk D, Siemidska L, Strzelczyk J
Department of Pathophysiology and Endocrinology, Silesian Medical University, Katowice, Poland.
Endocr Regul. 2001 Dec;35(4):217-22.
To assess mean 24-h serum concentrations of dehydroepianrosterone (DHEAS) in postmenopausal women with asthma before and after hormone replacement therapy (HRT).
Studies were performed in 55 asthmatic and 20 healthy postmenopausal women aged 48-60 before HRT and after 6 months of transdermal 17b-estradiol (E2) and medroxyprogesterone acetate treatment (cyclical method). Serum DHEAS concentrations were assessed with the use of RIA method.
In the group of postmenopausal asthmatic women treated with glucocorticoids the mean 24 h DHEAS serum levels were lower than in a similar group not treated with glucocorticoids and a control group of healthy postmenopausal women. However, in both groups of asthmatic women (e.g. glucocorticoid treated and untreated) a significant increase of mean daily DHEAS levels after 6 months of HRT was observed. The hormone concentrations did not change in control group.
Postmenopausal asthmatic women show diminished circadian dehydroepiandrosterone sulphate serum concentrations irrespective whether they were treated with glucocorticoids or not. However, after 6 months of hormonal replacement therapy in these groups increased levels of DHEA were found.
评估激素替代疗法（HRT）前后绝经后哮喘女性的24小时血清脱氢表雄酮（DHEAS）平均浓度。
对55名哮喘绝经后女性和20名健康绝经后女性进行研究，年龄在48 - 60岁，于HRT前以及经皮17β-雌二醇（E2）和醋酸甲羟孕酮治疗6个月后（周期疗法）进行研究。采用放射免疫分析法（RIA法）评估血清DHEAS浓度。
在接受糖皮质激素治疗的绝经后哮喘女性组中，24小时DHEAS血清平均水平低于未接受糖皮质激素治疗的类似组以及健康绝经后女性对照组。然而，在两组哮喘女性中（如接受糖皮质激素治疗组和未治疗组），HRT 6个月后观察到每日DHEAS平均水平显著升高。对照组激素浓度未发生变化。
绝经后哮喘女性无论是否接受糖皮质激素治疗，其昼夜硫酸脱氢表雄酮血清浓度均降低。然而，在这些组中进行6个月激素替代治疗后，发现DHEA水平升高。
