Chen Changyi, Li Min, Chai Hong, Yang Hui, Fisher William E, Yao Qizhi
Molecular Surgeon Research Center, Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, Texas, 77030, USA.
World J Surg. 2005 Mar;29(3):271-5. doi: 10.1007/s00268-004-7818-1.
Neuropilin-1 (NRP1) and neuropilin-2 (NRP2) are transmembrane glycoproteins that have been characterized as receptors for both semaphorins for neuronal guidance and vascular endothelial growth factor (VEGF) for angiogenesis. Biologic properties of NRPs have been linked to their unique domain structures. However, molecular interaction among NRPs, VEGF, and VEGF receptors is still not clear. Although several types of cancer cells can express NRPs, the role of NRPs in tumor pathogenesis is largely unknown. Thus, future investigations should include determining the effects and mechanisms of NRPs on proliferation, apoptosis, and migration of neuronal , endothelial, and cancer cells. Study of protein-protein interaction, signal transduction pathways, and NRP-mediated gene expression is particularly important to understand NRPs functions, which may have significant clinical applications in the treatment of neurological disorders, cardiovascular diseases, and certain cancers.
神经纤毛蛋白-1（NRP1）和神经纤毛蛋白-2（NRP2）是跨膜糖蛋白，已被鉴定为神经元导向的信号素和血管生成的血管内皮生长因子（VEGF）的受体。神经纤毛蛋白（NRPs）的生物学特性与其独特的结构域结构有关。然而，NRPs、VEGF和VEGF受体之间的分子相互作用仍不清楚。尽管几种类型的癌细胞可以表达NRPs，但NRPs在肿瘤发病机制中的作用在很大程度上尚不清楚。因此，未来的研究应包括确定NRPs对神经元、内皮细胞和癌细胞增殖、凋亡和迁移的影响及机制。蛋白质-蛋白质相互作用、信号转导通路和NRP介导的基因表达的研究对于理解NRPs的功能尤为重要，这可能在神经系统疾病、心血管疾病和某些癌症的治疗中具有重要的临床应用价值。
