经皮电刺激神经疗法（TENS）对轻度认知障碍老年人记忆力的影响。

Effects of transcutaneous electrical nerve stimulation (TENS) on memory in elderly with mild cognitive impairment.

作者信息

Luijpen Marijn W, Swaab Dick F, Sergeant Joseph A, van Dijk Koene R A, Scherder Erik J A

机构信息

Department of Clinical Neuropsychology, Vrije Universiteit, Van der Boechorststraat 1, 1081 BT Amsterdam, The Netherlands.

出版信息

Behav Brain Res. 2005 Mar 30;158(2):349-57. doi: 10.1016/j.bbr.2004.09.017.

DOI:10.1016/j.bbr.2004.09.017

PMID:15698902

Abstract

In previous studies, transcutaneous electrical nerve stimulation (TENS) was shown to have a positive effect on memory in Alzheimer's disease (AD) patients. Moreover, the reported effects appeared to be more beneficial in early stages of Alzheimer's disease compared to later stage intervention. Based on this stage-dependency, the present study examined the effects of TENS on memory in a preclinical stage of AD, i.e. in subjects with mild cognitive impairment (MCI). Our results suggest that TENS did not improve memory in a MCI population. Mechanisms that might underlie the absence of positive effects of the TENS treatment in a MCI population are discussed.

摘要

在先前的研究中，经皮电刺激神经疗法（TENS）被证明对阿尔茨海默病（AD）患者的记忆有积极影响。此外，与后期干预相比，所报告的效果在阿尔茨海默病早期似乎更有益。基于这种阶段依赖性，本研究考察了TENS对AD临床前期阶段，即轻度认知障碍（MCI）受试者记忆的影响。我们的结果表明，TENS并未改善MCI人群的记忆。文中讨论了TENS治疗在MCI人群中未产生积极效果可能的潜在机制。