Hudon Carol, Belleville Sylvie, Souchay Céline, Gély-Nargeot Marie-Christine, Chertkow Howard, Gauthier Serge
Centre de recherche de l'Institut universitaire de geriatrie de Montreal, PQ, Canada.
Neuropsychology. 2006 Sep;20(5):566-77. doi: 10.1037/0894-4105.20.5.566.
Two experiments examined different forms of gist and detail memory in people with Alzheimer's disease (AD) and those with amnestic mild cognitive impairment (MCI). In Experiment 1, 14 AD, 14 MCI, and 22 control participants were assessed with the Deese-Roediger-McDermott paradigm. Results indicated that false recognition of nonstudied critical lures (gist memory) was diminished in the AD compared with the MCI and control groups; the two latter cohorts performed similarly. In Experiment 2, 14 AD, 20 MCI, and 26 control participants were tested on a text memory task. Results revealed that recall of both macropropositions (gist information) and micropropositions (detail information) decreased significantly in AD and in MCI as compared with control participants. This experiment also revealed that the impairment was comparable between gist and detail memory. In summary, the results were consistent across experiments in the AD but not in the MCI participants. The discrepancy in MCI participants might be explained by differences in the degree of sensitivity of the experimental procedures and/or by the differences in the cognitive processes these procedures assessed.
两项实验研究了阿尔茨海默病（AD）患者和遗忘型轻度认知障碍（MCI）患者不同形式的要点记忆和细节记忆。在实验1中，对14名AD患者、14名MCI患者和22名对照参与者采用了迪斯-罗迪格-麦克德莫特范式进行评估。结果表明，与MCI组和对照组相比，AD组对未学习的关键诱饵的错误识别（要点记忆）有所减少；后两组表现相似。在实验2中，对14名AD患者、20名MCI患者和26名对照参与者进行了文本记忆任务测试。结果显示，与对照参与者相比，AD组和MCI组对宏观命题（要点信息）和微观命题（细节信息）的回忆均显著下降。该实验还表明，要点记忆和细节记忆的损伤程度相当。总之，AD组的实验结果一致，但MCI组不一致。MCI组参与者的差异可能是由实验程序的敏感度差异和/或这些程序所评估的认知过程差异所解释的。
