Health Service and Population Research, King's College London, London, UK
Health Service and Population Research, King's College London, London, UK.
BMJ Open. 2020 Apr 20;10(4):e035980. doi: 10.1136/bmjopen-2019-035980.
Non-pharmacological treatments are an important aspect of dementia care. A wide range of interventions have been trialled for mild dementia and mild cognitive impairment (MCI). However, the variety of outcome measures used in these trials makes it difficult to make meaningful comparisons. The objective of this study is to map trends in which outcome measures are used in trials of non-pharmacological treatments in MCI and mild dementia.
Scoping review.
EMBASE, PsychINFO, Medline and the Cochrane Register of Controlled Trials were searched from inception until February 2018. An additional search was conducted in April 2019 ELIGIBILITY: We included randomised controlled trials (RCTs) testing non-pharmacological interventions for people diagnosed with MCI or mild dementia. Studies were restricted to full RCTs; observational, feasibility and pilot studies were not included.
All outcome measures used by included studies were extracted and grouped thematically. Trends in the types of outcome measures used were explored by type of intervention, country and year of publication.
91 studies were included in this review. We extracted 358 individual outcome measures, of which 78 (22%) were used more than once. Cognitive measures were the most frequently used, with the Mini-Mental State Examination being the most popular.
Our findings highlight an inconsistency in the use of outcome measures. Cognition has been prioritised over other domains, despite previous research highlighting the importance of quality of life and caregiver measures. To ensure a robust evidence base, more research is needed to highlight which outcome measures should be used over others.
CRD42018102649.
非药物治疗是痴呆护理的一个重要方面。已经针对轻度痴呆和轻度认知障碍（MCI）试验了多种干预措施。然而，这些试验中使用的各种结果测量方法使得难以进行有意义的比较。本研究的目的是绘制在 MCI 和轻度痴呆的非药物治疗试验中使用结果测量方法的趋势图。
范围审查。
从开始到 2018 年 2 月，在 EMBASE、PsychINFO、Medline 和 Cochrane 对照试验登记处进行了搜索。2019 年 4 月进行了额外的搜索。
我们纳入了测试非药物干预措施的随机对照试验（RCT），用于诊断为 MCI 或轻度痴呆的人群。研究仅限于完整的 RCT；不包括观察性、可行性和试点研究。
提取纳入研究中使用的所有结果测量值，并按主题分组。通过干预类型、国家和出版年份探讨了使用的结果测量类型的趋势。
本综述共纳入 91 项研究。我们提取了 358 项单独的结果测量值，其中 78 项（22%）被多次使用。认知测量是最常用的，其中 Mini-Mental State Examination 是最受欢迎的。
我们的研究结果强调了结果测量方法使用的不一致性。尽管先前的研究强调了生活质量和护理人员措施的重要性，但认知功能仍优先于其他领域。为了确保有一个强大的证据基础，需要更多的研究来突出哪些结果测量方法应该优先于其他方法。
PROSPERO 注册号：CRD42018102649。
