Geelen Anouk, Brouwer Ingeborg A, Schouten Evert G, Maan Arie C, Katan Martijn B, Zock Peter L
Wageningen Centre for Food Sciences and Division of Human Nutrition, Wageningen University, Wageningen, Netherlands.
Am J Clin Nutr. 2005 Feb;81(2):416-20. doi: 10.1093/ajcn.81.2.416.
A large body of evidence suggests that n-3 fatty acids from fish prevent fatal heart disease. They may be an effective and safe alternative to drug treatment for reducing the risk of arrhythmia and sudden cardiac death.
We investigated the effect of n-3 fatty acids on heart rate and premature ventricular complexes (PVCs), a common form of arrhythmia that may trigger arrhythmias that are more life-threatening.
Patients (n=84) with >or=1440 PVCs/24 h in a previous Holter recording were randomly assigned to receive 1.5 g/d of either n-3 fatty acids or placebo. Two 24-h Holter recordings were made at baseline, and 2 were made after an intervention of approximately 14 wk.
Treatment did not significantly affect the number of PVCs. The number decreased in the fish-oil group by 867/24 h more than it decreased in placebo group (95% CI: -3187, 1453). However, the mean 24-h heart rate was significantly affected, decreasing in the fish-oil group by a mean of 2.1 beats/min more than it decreased in the placebo group (95% CI: -3.9, -0.3).
Supplementation with 1.5 g n-3 fatty acids/d from fish does not substantially suppress the number of PVCs in a patient population with frequent PVCs. However, n-3 fatty acids decreased heart rate by 2.1 beats/min, a significant decrease that predicts a lower risk of sudden death.
大量证据表明，鱼类中的n-3脂肪酸可预防致命性心脏病。它们可能是降低心律失常和心源性猝死风险的药物治疗的有效且安全的替代方法。
我们研究了n-3脂肪酸对心率和室性早搏（PVCs）的影响，PVCs是一种常见的心律失常形式，可能引发更具生命威胁的心律失常。
在之前的动态心电图记录中，24小时PVCs≥1440次的患者（n = 84）被随机分配接受1.5克/天的n-3脂肪酸或安慰剂。在基线时进行两次24小时动态心电图记录，在大约14周的干预后再进行两次。
治疗对PVCs的数量没有显著影响。鱼油组的PVCs数量减少幅度比安慰剂组多867次/24小时（95%可信区间：-3187, 1453）。然而，24小时平均心率受到显著影响，鱼油组的平均心率下降幅度比安慰剂组多2.1次/分钟（95%可信区间：-3.9, -0.3）。
每天补充1.5克来自鱼类的n-3脂肪酸并不能显著抑制频发PVCs患者群体中的PVCs数量。然而，n-3脂肪酸使心率降低了2.1次/分钟，这一显著下降预示着猝死风险降低。
