Oner Taliha, Ozdemir Rahmi, Doksöz Onder, Genc Dildar B, Guven Baris, Demirpence Savas, Yilmazer Murat M, Yozgat Yilmaz, Mese Timur, Tavli Vedide
1SisliEtfal Training and Research Hospital,Department of Pediatric Cardiology,Sisli,Istanbul,Turkey.
2Dr. Behçet Uz Children's Hospital,Department of Pediatric Cardiology,Alsancak,Izmir,Turkey.
Cardiol Young. 2018 Jul;28(7):949-954. doi: 10.1017/S1047951118000574. Epub 2018 May 15.
Premature ventricular contractions are accepted as benign in structurally normal hearts. However, reversible cardiomyopathy can sometimes develop. Omega-3 polyunsaturated fatty acids have anti-arrhythmic properties in animals and humans.AimWe evaluated left ventricular function in children with premature ventricular contractions with normal cardiac anatomy and assessed the impact of omega-3 fatty acid supplementation on left ventricular function in a prospective trial.
A total of 25 patients with premature ventricular contraction, with more than 2% premature ventricular contractions on 24-hour Holter electrocardiography, and 30 healthy patients were included into study. All patients underwent electrocardiography, left ventricular M-mode echocardiography, and myocardial performance index testing. Patients with premature ventricular contraction were given omega-3 fatty acids at a dose of 1 g/day for 3 months, and control echocardiography and 24-hour Holter electrocardiography were performed. Neither placebo nor omega-3 fatty acids were given to the control group.
Compared with the values of the control group, the patients with premature ventricular contraction had significantly lower fractional shortening. The myocardial performance index decreased markedly in the patient groups. The mean heart rate and mean premature ventricular contraction percentage of Group 2 significantly decreased in comparison with their baseline values after the omega-3 supplementation.
In conclusion, premature ventricular contractions can lead to systolic cardiac dysfunction in children. Omega-3 supplementation may improve cardiac function in children with premature ventricular contractions. This is the first study conducted in children to investigate the possible role of omega-3 fatty acid supplementation on treatment of premature ventricular contractions.
室性早搏在心脏结构正常时被认为是良性的。然而，有时会发展为可逆性心肌病。ω-3多不饱和脂肪酸在动物和人类中具有抗心律失常特性。
我们在一项前瞻性试验中评估了心脏解剖结构正常的室性早搏患儿的左心室功能，并评估了补充ω-3脂肪酸对左心室功能的影响。
共有25例室性早搏患者（24小时动态心电图显示室性早搏超过2%）和30例健康患者纳入研究。所有患者均接受了心电图、左心室M型超声心动图和心肌性能指数测试。室性早搏患者给予1克/天的ω-3脂肪酸，持续3个月，并进行对照超声心动图和24小时动态心电图检查。对照组既不给予安慰剂也不给予ω-3脂肪酸。
与对照组相比，室性早搏患者的缩短分数显著降低。患者组的心肌性能指数明显下降。补充ω-3脂肪酸后，第2组的平均心率和平均室性早搏百分比与基线值相比显著降低。
总之，室性早搏可导致儿童收缩期心脏功能障碍。补充ω-3脂肪酸可能改善室性早搏患儿的心脏功能。这是首次在儿童中进行的研究，旨在探讨补充ω-3脂肪酸在治疗室性早搏中的可能作用。
