Wang Ning-Lu, Liou Yann-Lin, Lin Mao-Tsun, Lin Chia-Li, Chang Cheng-Kuei
Institute of Physiology, National Yang-Ming University Medical School, Taipei, Taiwan.
J Pharmacol Sci. 2005 Feb;97(2):253-65. doi: 10.1254/jphs.fp0040793. Epub 2005 Feb 5.
The aim of this study was to investigate the effect of Shengmai San (SMS), a traditional Chinese herbal medicine, on heatstroke-induced circulatory shock and oxidative damage in the brain in rats. Anesthetized rats were exposed to a high ambient temperature (43 degrees C) to induce heatstroke. After the onset of heatstroke, the values of mean arterial pressure, cerebral perfusion pressure, cerebral blood flow, and brain partial pressure of O(2) were all significantly lower than those in normothermic controls. However, the values of intracranial pressure, brain and colonic temperatures, and brain levels of free radicals, lipid peroxidation, and cellular ischemia and damage markers were all greater in heatstroke rats compared with those of normothermic controls. Pretreatment or post-treatment with SMS significantly reduced the hypotension, intracranial hypertension, cerebral hypoperfusion and hypoxia and increased levels of ischemia and damage markers in the brain during heatstroke. The protective effects exerted by SMS pretreatment is superior to those of SMS post-treatment. The results demonstrate that SMS is effective for prevention and repair of circulatory shock and ischemic and oxidative damage in the brain during heatstroke.
本研究旨在探讨中药生脉散（SMS）对大鼠中暑诱导的循环性休克及脑氧化损伤的影响。将麻醉的大鼠暴露于高温环境（43℃）以诱导中暑。中暑发作后，平均动脉压、脑灌注压、脑血流量及脑氧分压值均显著低于正常体温对照组。然而，与正常体温对照组相比，中暑大鼠的颅内压、脑和结肠温度以及脑自由基水平、脂质过氧化水平和细胞缺血及损伤标志物水平均更高。中暑期间，用SMS进行预处理或后处理可显著减轻低血压、颅内高压、脑灌注不足和缺氧，并降低脑缺血及损伤标志物水平。SMS预处理的保护作用优于后处理。结果表明，SMS对中暑期间循环性休克及脑缺血和氧化损伤具有预防和修复作用。
