Green Ben, Pettit Tor, Faith Lesley, Seaton Kristof
Cheadle Royal Hospital, Department of Psychiatry, University of Liverpool, UK.
Curr Med Res Opin. 2004 Dec;20(12):1877-81. doi: 10.1185/030079904X12708.
This is a review of the uses of levomepromazine in psychiatry, based upon MEDLINE, PSYCLIT and EMBASE literature searches. The main indications for this drug in psychiatry are schizophrenia and schizoaffective disorder. Levomepromazine's sedative properties particularly fit it to use in psychiatric intensive care. There is also some evidence to suggest it has efficacy in drug-resistant psychosis, although this property of the drug does require further research. In other areas of medicine levomepromazine has been used in: alleviating bronchoconstriction; as a preoperative sedative; in terminal pain control and postoperative analgesia; and in the control of nausea. Some antimycobacterial properties have been recorded. The drug should not be prescribed to patients at high risk of accidental or suicidal overdose.
这是一篇基于医学文献数据库（MEDLINE）、心理学文摘数据库（PSYCLIT）和荷兰医学文摘数据库（EMBASE）的文献检索，对左美丙嗪在精神病学领域应用的综述。该药物在精神病学中的主要适应症为精神分裂症和分裂情感性障碍。左美丙嗪的镇静特性使其特别适用于精神科重症监护。也有一些证据表明它对耐药性精神病有效，不过该药物的这一特性确实需要进一步研究。在医学的其他领域，左美丙嗪已被用于：缓解支气管收缩；作为术前镇静剂；用于晚期疼痛控制和术后镇痛；以及控制恶心。已记录到其具有一些抗分枝杆菌特性。不应给有意外或自杀性过量用药高风险的患者开此药。
