Bucardo F, Meza-Lucas A, Espinoza F, García-Jerónimo R C, García-Rodea R, Correa D
Departamento de Microbiología y Parasitología, Universidad Nacional Autónoma de Nicaragua, León, Nicaragua.
Ann Trop Med Parasitol. 2005 Jan;99(1):41-5. doi: 10.1179/136485905X19856.
The Taenia solium taeniasis/cysticercosis complex is an important public-health problem in several countries, where many epileptic seizures appear to be associated with neurocysticercosis. As few data on this problem in Nicaragua exist, the seroprevalence of antibodies reacting with antigens from T. solium cysticerci was investigated among 88 Nicaraguan epileptics (45 males and 43 females, aged 6-53 years). In questionnaire-based interviews, each adult subject and a caregiver of each child investigated were asked about potential risk factors for taeniasis/cysticercosis. When a serum sample from each subject was then checked for anti-cysticercus antibodies, 8.0% of the subjects were found seropositive by ELISA and 14.8% by western blotting. Five samples (all from individuals who had been epileptic for > 5 years) were positive in both tests. When the level of association between each potential risk factor and seropositivity (in ELISA or by blotting) was evaluated, the only statistically significant association detected was that between a positive ELISA and the subject living in a household where pigs were raised (odds ratio = 5.18; 95% confidence interval = 0.8-41.6; P = 0.05). The bands most frequently recognized in the western blots (of 50, 42-39, 24 and 14 kDa) were those previously reported. The results indicate that, in the city of Léon, cysticercosis may be endemic and the cause of a significant proportion of the epilepsy recorded.
猪带绦虫病/囊尾蚴病复合体在多个国家是一个重要的公共卫生问题，在这些国家，许多癫痫发作似乎与神经囊尾蚴病有关。由于尼加拉瓜关于这个问题的数据很少，因此在88名尼加拉瓜癫痫患者（45名男性和43名女性，年龄6 - 53岁）中调查了与猪带绦虫囊尾蚴抗原发生反应的抗体的血清阳性率。在基于问卷的访谈中，询问了每位成年受试者以及每位接受调查儿童的照顾者关于绦虫病/囊尾蚴病的潜在风险因素。随后检查每位受试者的血清样本中的抗囊尾蚴抗体，通过酶联免疫吸附测定（ELISA）发现8.0%的受试者血清呈阳性，通过蛋白质印迹法发现14.8%的受试者血清呈阳性。有5个样本（均来自癫痫发作超过5年的个体）在两种检测中均呈阳性。当评估每个潜在风险因素与血清阳性（通过ELISA或蛋白质印迹法）之间的关联程度时，检测到的唯一具有统计学意义的关联是ELISA阳性与居住在养猪家庭的受试者之间的关联（优势比 = 5.18；95%置信区间 = 0.8 - 41.6；P = 0.05）。蛋白质印迹法中最常识别的条带（50、42 - 39、24和14 kDa）是先前报道过的。结果表明，在莱昂市，囊尾蚴病可能是地方性疾病，并且是所记录的相当一部分癫痫的病因。
