Nkouawa Agathe, Dschanou Armel Romeo, Moyou-Somo Roger, Sako Yasuhito, Ito Akira
Department of Parasitology, Asahikawa Medical University, Asahikawa, Japan; Medical Research Centre, Institute of Medical Research and Medicinal Plants Studies (IMPM), Ministry of Scientific Research and Innovation, Yaoundé, Cameroon.
Université des Montagnes, Bangangté, Cameroon.
Acta Trop. 2017 Jan;165:116-120. doi: 10.1016/j.actatropica.2015.12.019. Epub 2015 Dec 30.
Cysticercosis caused by the larvae of Taenia solium is a serious and emerging threat to public health in the endemic areas as well as in the non-endemic areas. Neurocysticercosis, an affection of the central nervous system is a leading cause of epilepsy in endemic areas. This study was carried out to investigate human cysticercosis, taeniasis and risk factors, and also their association with epilepsy in Bangoua, west Cameroon where epilepsy is highly prevalent. Out of 384 people investigated, 12 (3.1%) exhibited antibody response against low molecular weight antigens of T. solium by ELISA. Immunoblot revealed that six persons (1.6%) were seropositive with the same antigens. Among 61 epileptic patients, only one was seropositive by immunoblot and the study did not find any statistically significant difference (P>0.05) in seropositivity to T. solium between epileptic persons (1/61, 1.6%) and non-epileptic group (5/323, 1.5%). In addition, cysticercosis was associated with households eating pork meat from pigs slaughtered at home, but not with other factors. The risk factors including pig farming, the consumption of pork meat, vegetables, and non-drinkable water were attenuated by the relatively good hygiene and pig husbandry practices of the population. No egg of Taenia was found in stool by microscopic examination. All data obtained in this study suggested that cysticercosis might not be the principal causative agent of epilepsy in this area.
由猪带绦虫幼虫引起的囊尾蚴病，对流行地区和非流行地区的公众健康构成了严重且新出现的威胁。神经囊尾蚴病，即中枢神经系统的一种疾病，是流行地区癫痫的主要病因。本研究旨在调查喀麦隆西部班戈阿地区的人体囊尾蚴病、绦虫病及其危险因素，以及它们与癫痫的关联，该地区癫痫高度流行。在384名接受调查的人中，有12人（3.1%）通过酶联免疫吸附测定（ELISA）显示出针对猪带绦虫低分子量抗原的抗体反应。免疫印迹法显示，有6人（1.6%）对相同抗原有血清阳性反应。在61名癫痫患者中，只有1人通过免疫印迹法呈血清阳性，并且该研究未发现癫痫患者（1/61，1.6%）和非癫痫组（5/323，1.5%）之间对猪带绦虫的血清阳性率有任何统计学上的显著差异（P>0.05）。此外，囊尾蚴病与食用自家宰杀猪肉的家庭有关，但与其他因素无关。包括养猪、食用猪肉、蔬菜和不可饮用的水等危险因素，因当地居民相对良好的卫生和养猪习惯而得到缓解。通过显微镜检查，在粪便中未发现绦虫卵。本研究获得的所有数据表明，囊尾蚴病可能不是该地区癫痫的主要致病因素。
