Barnhart T E, Converse A K, Dabbs K A, Schueller M J, Stone C K, Nickles R J, Roberts A D
Medical Physics, University of Wisconsin, 1500 N. Highland Ave. T-121 Waisman Center, Madison, WI 53705, USA.
Appl Radiat Isot. 2005 Apr;62(4):525-32. doi: 10.1016/j.apradiso.2004.08.044.
Production of 17F (t1/2=65 s) in the form of [17F] F2 has been achieved using both the 20Ne(p,alpha)17F and 16O(d,n)17F reactions with 11 MeV protons and 6 MeV deuterons, respectively. Yields have proven suitable for subsequent radiosynthesis of the blood flow tracer, [17F]CH3F (>60 mCi in saline), currently in use for fast repetition human studies of regional cerebral blood flow with positron emission tomography. Thick target yields of 15 mCi /microA for protons and 44 mCi/microA for deuterons have been measured for [17F]F2.
分别使用能量为11兆电子伏的质子和6兆电子伏的氘核，通过20Ne(p,α)17F和16O(d,n)17F反应已实现以[17F]F2形式生产17F（半衰期t1/2 = 65秒）。已证明产率适用于后续血流示踪剂[17F]CH3F的放射性合成（在生理盐水中>60毫居里），目前该示踪剂正用于通过正电子发射断层扫描对局部脑血流进行快速重复的人体研究。已测量出[17F]F2的厚靶产率，质子为15毫居里/微安，氘核为44毫居里/微安。
