Bergman J, Solin O
Turku Pet Centre, Abo Akademi University, Finland.
Nucl Med Biol. 1997 Oct;24(7):677-83. doi: 10.1016/s0969-8051(97)00078-4.
The aim of this work was to develop a method to produce 18F-labeled fluorine gas ([18F]F2) with high specific radioactivity (SA, radioactivity/mass-ratio). 18F-Labeled methyl fluoride ([18F]CH3F) was synthesized from [18F]F-aq and mixed with carrier F2 in an inert neon matrix. The constituents were atomized in an electric discharge, after which a rearrangement and 18F for 19F exchange took place. [18F]F2 with a specific radioactivity of up to 55 GBq/mumol is available for the labeling synthesis of tracers for positron emission tomography (PET).
这项工作的目的是开发一种方法，以生产具有高比活度（SA，放射性/质量比）的18F标记氟气（[18F]F2）。由[18F]F-水溶液合成18F标记的氟甲烷（[18F]CH3F），并在惰性氖基质中与载体F2混合。成分在放电中雾化，之后发生重排以及18F与19F的交换。比活度高达55 GBq/μmol的[18F]F2可用于正电子发射断层扫描（PET）示踪剂的标记合成。
