Casella V, Ido T, Wolf A P, Fowler J S, MacGregor R R, Ruth T J
J Nucl Med. 1980 Aug;21(8):750-7.
Interest in fluorine- 18 as a label in radiopharmaceutical studies has led to the development of a method for the production of decicuries of anhydrous 18F-F2 using the 20Ne(d, alpha) 18F reaction. The amount of anhydrous 18F-F2 that can be removed from the target is a function of target pressure and carrier cokncentration increasing with rising target pressure and decreasing with decreasing carrier concentration. At a target pressure of 24 atmospheres and a carrier concentration of 0.1% F2, nearly 95% of the theoretical yield of fluorine- 18 produced can be removed and up to 85% delivered through a 10o-m stainless steel tube to the reaction chamber. Other functions affecting yield--including target design, target-gas handling and purity--have been addressed. Thick target yields for 14.0- and 9.4-MeV deuterons on target were measured to be 82 and 67 mCl/microA at saturation. With the BNL 60-in. cyclotron, production okf 600-800 mCl of 18F-F2 with a specific activity of approximately 10 mCi/mumole has been in effect since 1976.
在放射性药物研究中，对氟 - 18作为标记物的兴趣促使人们开发出一种利用20Ne(d, α) 18F反应生产数居里无水18F - F2的方法。可从靶中去除的无水18F - F2的量是靶压力和载体浓度的函数，随靶压力升高而增加，随载体浓度降低而减少。在24个大气压的靶压力和0.1% F2的载体浓度下，所产生的氟 - 18理论产量的近95%可被去除，并且高达85%可通过一根10o - m不锈钢管输送到反应室。其他影响产率的因素——包括靶的设计、靶气体处理和纯度——也已得到解决。在饱和状态下，14.0 MeV和9.4 MeV氘核轰击靶的厚靶产率分别测得为82和67 mCl/μA。自1976年以来，利用布鲁克海文国家实验室60英寸回旋加速器，已能有效生产600 - 800 mCl的18F - F2，其比活度约为10 mCi/μmol。
