Kothare Sanjeev V
Department of Pediatrics, Division of Neurology, St Christopher's Hospital for Children, Drexel University College of Medicine, Erie Avenue at Front Street, Philadelphia, PA 19134, USA.
Eur J Paediatr Neurol. 2005;9(1):23-6. doi: 10.1016/j.ejpn.2004.11.002. Epub 2004 Dec 25.
Cyclical vomiting syndrome (CVS), and abdominal migraine (AM) are relatively unusual periodic syndromes, generally believed to be migraine equivalents, and are characterized by recurrent and severe paroxysmal episodes of vomiting and/or abdominal pain lasting hours to days, separated by weeks to months of no symptoms. Flunarizine is a calcium channel-blocking agent that has been used successfully as a prophylactic agent in the prevention of both childhood and adult-onset migraine syndromes. The purpose of this study was to evaluate the efficacy of flunarizine as a prophylactic/preventive agent in the treatment of CVS and AM. Eight children with CVS and 10 children with AM were included in the study. The mean dose of flunarizine was 5 mg/day in children with CVS, and 7.5 mg/day in children with AM. Follow-up ranged from 6 to 24 months (mean 13 months). There was a 57% reduction in frequency and 44% reduction in duration of attacks of CVS, and a 61% reduction in frequency and 51% reduction in duration of attacks of AM. Sixty-four percent of patients with CVS and AM had history of episodic recurrent headaches with 60% reduction in frequency of attacks on treatment. Flunarizine showed to be equally efficacious than previously tried therapies in the prophylaxis of a small cohort of patients with CVS and AM.
周期性呕吐综合征（CVS）和腹型偏头痛（AM）是相对罕见的周期性综合征，通常被认为是偏头痛的等效病症，其特征为反复出现严重的阵发性呕吐和/或腹痛发作，持续数小时至数天，发作间歇期为无症状的数周或数月。氟桂利嗪是一种钙通道阻滞剂，已成功用作预防儿童和成人偏头痛综合征的预防药物。本研究的目的是评估氟桂利嗪作为预防/预防性药物治疗CVS和AM的疗效。该研究纳入了8名患有CVS的儿童和10名患有AM的儿童。CVS患儿的氟桂利嗪平均剂量为5毫克/天，AM患儿为7.5毫克/天。随访时间为6至24个月（平均13个月）。CVS发作频率降低了57%，发作持续时间缩短了44%；AM发作频率降低了61%，发作持续时间缩短了51%。64%的CVS和AM患者有发作性反复头痛病史，治疗后发作频率降低了60%。在一小群CVS和AM患者中，氟桂利嗪在预防方面显示出与先前尝试的疗法同样有效。
