Günther Göran, Lindquist Lars
Euro Surveill. 2005 Jan;10(1):2-3.
The study by Stefanoff et al raises two important questions concerning tick-borne encephalitis (TBE) virus infections. First, the lack of a generally accepted case definition and secondly the quality of national surveillance of TBE cases. Ideally, reported cases should be confirmed and the clinically relevant cases with central nervous system (CNS) disease should be separated from febrile cases without CNS manifestations. The surveillance of TBE in the European countries is not uniform and not always mandatory. Efforts to reach a final diagnosis, especially in less severe cases and in children, varies as well as the awareness of the disease in low endemic regions. The only relevant and stable basis for national surveillance is cases with established CNS disease, although immunity to TBE virus after less severe febrile illness is of interest on individual basis. The ratio of non-CNS disease to CNS disease is generally believed to be about three, but there are regional differences in virulence. Significantly, age related differences are basically unknown.
斯特凡诺夫等人的研究提出了两个关于蜱传脑炎（TBE）病毒感染的重要问题。第一，缺乏普遍接受的病例定义；第二，TBE病例的国家监测质量。理想情况下，报告的病例应得到确诊，患有中枢神经系统（CNS）疾病的临床相关病例应与无CNS表现的发热病例区分开来。欧洲国家对TBE的监测并不统一，也并非总是强制性的。在病情不太严重的病例和儿童中，做出最终诊断的努力各不相同，低流行地区对该疾病的认知也存在差异。国家监测唯一相关且稳定的基础是确诊患有CNS疾病的病例，尽管病情不太严重的发热性疾病后对TBE病毒的免疫力在个体层面上也值得关注。一般认为非CNS疾病与CNS疾病的比例约为3，但毒力存在地区差异。值得注意的是，基本不清楚与年龄相关的差异。
