老年患者中风后抑郁的病理相关性
Pathological correlates of poststroke depression in elderly patients.
作者信息
Bozikas Vasilis P, Gold Gabriel, Kövari Enikö, Herrmann Francois, Karavatos Athanasios, Giannakopoulos Panteleimon, Bouras Constantin
机构信息
Department of Psychiatry, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece.
出版信息
Am J Geriatr Psychiatry. 2005 Feb;13(2):166-9. doi: 10.1176/appi.ajgp.13.2.166.
OBJECTIVE
The authors examined the relationship between poststroke depression and location of stroke.
METHODS
They performed a clinicopathological analysis of 95 consecutively autopsied elderly initial-stroke survivors.
RESULTS
The severity of brain vessel arteriosclerosis and frequency of brain vascular lesions were not significantly different between 21 cases with poststroke depression and 74 cases without. Earlier death was the only variable significantly associated with poststroke depression. No lesion pattern characterized the depression group.
CONCLUSIONS
Neuropathological data confirm that depression is associated with worse prognosis in elderly stroke patients and lend support to the hypothesis that psychological rather than neurological factors are the main determinants of poststroke depression.
目的
作者研究了中风后抑郁与中风部位之间的关系。
方法
他们对95例连续接受尸检的老年初发中风幸存者进行了临床病理分析。
结果
21例中风后抑郁患者与74例无抑郁患者之间，脑血管动脉硬化的严重程度和脑血管病变的发生率无显著差异。较早死亡是与中风后抑郁显著相关的唯一变量。抑郁组没有特征性的病变模式。
结论
神经病理学数据证实，抑郁与老年中风患者预后较差有关，并支持心理因素而非神经因素是中风后抑郁主要决定因素的假说。
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