Department of Psychiatry, Walter Reed Army Medical Center, Washington, DC 20307-5001, USA.
Psychiatr Q. 2010 Mar;81(1):73-9. doi: 10.1007/s11126-009-9120-8.
Post-stroke depression has been noted to be one of the most frequent complications of stroke with an estimated prevalence of as high as 80%. However, the incidence of stroke in the young is extremely low and evidence based therapy for this complication is quite limited. The case of a 28-year-old woman who experienced a basilar artery vasospasmic stroke resulting in anoxic brain injury to the midbrain and paramedian thalamus is presented, along with a literature review of psychiatric complications of this injury to include post-stroke depression (PSD). Therapeutic modalities such as TCAs, SSRIs, atypical antipsychotics and stimulant medications are also reviewed as these medications may aid in the treatment of such patients but may also contribute to psychiatric sequelae.
脑卒中后抑郁是脑卒中最常见的并发症之一，其发病率估计高达 80%。然而，年轻人患脑卒中的发病率极低，针对这种并发症的循证治疗相当有限。本文报告了一例 28 岁女性基底动脉血管痉挛性脑卒中病例，导致中脑和旁正中丘脑缺氧性脑损伤，并对该损伤的精神并发症包括脑卒中后抑郁（PSD）进行了文献复习。还回顾了三环类抗抑郁药、SSRIs、非典型抗精神病药和兴奋剂等治疗方法，因为这些药物可能有助于治疗此类患者，但也可能导致精神后遗症。
