Yang Xiaoming, Zhu Wei, Chen Jun, Qian Zhiyu, Xie Jimin
School of Chemistry and Chemical Engineering, Jiangsu University, Zhenjiang 212013.
Zhong Yao Cai. 2004 Sep;27(9):661-3.
Ginkgolic acids and their three monomers were separated from ginkgo sarcotestas. The anti-bacterium activity of ginkgolic acids were tested. The relation between the anti-bacterium activity and side chain of ginkgolic acid were studied.
The MIC of ginkgolic acids and their three monomers and salicylic acid were tested.
Ginkgolic acid has strong inhibitive effect on G+-bacterium. Salicylic acid has no side chain, so no anti-bacterial activity. When the length of gingkolic acid side chain is C13:0, it has the strongest anti-bacterial activity in three monomers.
The side chain of ginkgolic acid is the key functional group that possessed anti-bacterial activity. The length of Ginkgolic acid was the main effective factor of anti-bacterial activity.
从银杏外种皮中分离出银杏酸及其三种单体，测试银杏酸的抗菌活性，研究银杏酸抗菌活性与侧链的关系。
测试银杏酸及其三种单体和水杨酸的最低抑菌浓度（MIC）。
银杏酸对革兰氏阳性菌有较强抑制作用。水杨酸无侧链，无抗菌活性。当银杏酸侧链长度为C13:0时，在三种单体中抗菌活性最强。
银杏酸的侧链是具有抗菌活性的关键官能团，银杏酸的长度是抗菌活性的主要影响因素。
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