Genetics and genomics are being widely applied in an effort to unlock the secrets of psoriasis. At the same time, an explosion of exciting new biological therapies has brought large numbers of patients into clinical trials. Opportunities exist for synergism between therapeutic trials and genetic/genomic studies of psoriasis (and psoriatic arthritis). This article reviews existing clinical registries of psoriasis, with an emphasis on genetic studies; compares and contrasts the types of information necessary for genetic, genomic, and clinical registries; and considers the impact of patient privacy on the use of registries for both clinical and genetic studies.