University of Ottawa, Ottawa, Ontario, Canada.
Mustafa Kemal University, Hatay, Turkey.
Arthritis Care Res (Hoboken). 2020 Jan;72(1):63-68. doi: 10.1002/acr.23836.
Psoriatic arthritis (PsA) has a genetic background. Approximately 40% of patients with psoriasis or PsA have a family history of psoriasis or PsA, which may affect disease features. The aim of this study was to assess the effects of family history of psoriasis and PsA on disease phenotypes.
Data from 1,393 patients recruited in the longitudinal, multicenter Psoriatic Arthritis International Database were analyzed. The effects of family history of psoriasis and/or PsA on characteristics of psoriasis and PsA were investigated using logistic regression.
A total of 444 patients (31.9%) had a family history of psoriasis and/or PsA. These patients were more frequently women, had earlier onset of psoriasis, more frequent nail disease, enthesitis, and deformities, and less frequently achieved minimal disease activity. Among 444 patients, 335 only had psoriasis in their family, 74 had PsA, and 35 patients were not certain about having PsA and psoriasis in their family, so they were excluded from further analysis. In the multivariate analysis, family history of psoriasis was associated with younger age at onset of psoriasis (odds ratio [OR] 0.976) and presence of enthesitis (OR 1.931), whereas family history of PsA was associated with lower risk of plaque psoriasis (OR 0.417) and higher risk of deformities (OR 2.557). Family history of PsA versus psoriasis showed increased risk of deformities (OR 2.143) and lower risk of plaque psoriasis (OR 0.324).
Family history of psoriasis and PsA impacts skin phenotypes, musculoskeletal features, and disease severity. The link between family history of psoriasis/PsA and pustular/plaque phenotypes may point to a different genetic background and pathogenic mechanisms in these subsets.
银屑病关节炎（PsA）具有遗传背景。大约 40%的银屑病或 PsA 患者有银屑病或 PsA 的家族史，这可能会影响疾病特征。本研究旨在评估银屑病和 PsA 的家族史对疾病表型的影响。
对来自纵向、多中心银屑病关节炎国际数据库的 1393 例患者的数据进行分析。使用逻辑回归分析银屑病和/或 PsA 家族史对银屑病和 PsA 特征的影响。
共有 444 例（31.9%）患者有银屑病和/或 PsA 的家族史。这些患者更常见于女性，银屑病发病年龄更早，更频繁出现指甲疾病、附着点炎和畸形，且达到最小疾病活动度的比例更低。在 444 例患者中，335 例仅在家族中存在银屑病，74 例存在 PsA，35 例患者不确定家族中是否存在 PsA 和银屑病，因此将其排除在进一步分析之外。在多变量分析中，银屑病家族史与银屑病发病年龄较小（比值比 [OR] 0.976）和附着点炎存在（OR 1.931）相关，而 PsA 家族史与斑块型银屑病风险较低（OR 0.417）和畸形风险较高（OR 2.557）相关。PsA 家族史与银屑病家族史相比，畸形风险增加（OR 2.143），斑块型银屑病风险降低（OR 0.324）。
银屑病和 PsA 的家族史影响皮肤表型、肌肉骨骼特征和疾病严重程度。银屑病/PsA 家族史与脓疱型/斑块型表型之间的关联可能表明这些亚组存在不同的遗传背景和发病机制。
