Frampton Arthur R, Goins William F, Cohen Justus B, von Einem Jens, Osterrieder Nikolaus, O'Callaghan Dennis J, Glorioso Joseph C
Department of Molecular Genetics and Biochemistry, University of Pittsburgh School of Medicine, E1246 Biomedical Science Tower, Pittsburgh, PA 15261, USA.
J Virol. 2005 Mar;79(5):3169-73. doi: 10.1128/JVI.79.5.3169-3173.2005.
The well-described herpesvirus entry receptors HveA (TNFRSF14), HveB (nectin 2), and HveC (nectin 1) have been shown to mediate the entry of alphaherpesviruses. Our findings showed that the alphaherpesvirus equine herpesvirus 1 (EHV-1) efficiently entered and replicated in CHO-K1 cells that lack the entry receptors HveA, HveB, and HveC, demonstrating that EHV-1 utilizes a unique entry receptor. As with other alphaherpesviruses, efficient EHV-1 entry was dependent on glycoprotein D and cell surface glycosaminoglycans.
已充分描述的疱疹病毒进入受体HveA(TNFRSF14)、HveB(nectin 2)和HveC(nectin 1)已被证明可介导甲型疱疹病毒的进入。我们的研究结果表明,甲型疱疹病毒马疱疹病毒1型(EHV-1)能在缺乏进入受体HveA、HveB和HveC的CHO-K1细胞中高效进入并复制,这表明EHV-1利用了一种独特的进入受体。与其他甲型疱疹病毒一样,EHV-1的有效进入依赖于糖蛋白D和细胞表面糖胺聚糖。