Dernellis John, Panaretou Maria
Department of Cardiology, Vostanion Hospital, Mytilini, Greece.
Hypertension. 2005 Mar;45(3):426-31. doi: 10.1161/01.HYP.0000157818.58878.93. Epub 2005 Feb 14.
Aortic stiffness may predict progression to hypertension beyond classic risk factors. In a longitudinal study, we assessed the predictive value of aortic stiffness on future hypertension in nonhypertensive subjects with blood pressure (BP) <140/90. Aortic stiffness was determined by echocardiography at baseline in 2512 subjects. The follow-up time was 4 years. A stepwise increase in hypertension incidence occurred across the male and older participants: 3.8% of young female individuals, 11.5% of young male, 26.1% of old female, and 58.8% of old male subjects progressed to hypertension over 4 years. In multivariate analysis, aortic stain, distensibility, and stiffness index (beta) remained significantly associated with the progression to future hypertension after adjustment to classic risk factors in men and women and in young and old populations. This study provides the first direct evidence to our knowledge in a longitudinal study that aortic stiffness is an independent predictor of progression to hypertension in nonhypertensive individuals.
主动脉僵硬度可能预示着在经典危险因素之外向高血压的进展。在一项纵向研究中，我们评估了主动脉僵硬度对血压（BP）<140/90的非高血压受试者未来发生高血压的预测价值。通过超声心动图在基线时测定了2512名受试者的主动脉僵硬度。随访时间为4年。高血压发病率在男性和老年参与者中呈逐步上升趋势：在4年中，3.8%的年轻女性、11.5%的年轻男性、26.1%的老年女性和58.8%的老年男性受试者进展为高血压。在多变量分析中，在对男性和女性以及年轻和老年人群的经典危险因素进行调整后，主动脉应变、扩张性和僵硬度指数（β）仍与未来高血压的进展显著相关。据我们所知，这项研究在纵向研究中首次提供了直接证据，表明主动脉僵硬度是非高血压个体进展为高血压的独立预测因素。
