Lapierre-Nguyen Stephanie, Buffington Tyler, Chonchol Michel, Nowak Kristen L
Division of Renal Diseases and Hypertension, University of Colorado Anschutz Medical Campus, Aurora, CO, United States.
Front Physiol. 2025 Apr 25;16:1582777. doi: 10.3389/fphys.2025.1582777. eCollection 2025.
Patients with chronic kidney disease (CKD) demonstrate accelerated vascular aging which contributes to an increased risk of cardiovascular disease (CVD). Impaired vascular health in CKD is characterized by both functional and structural alterations to the vasculature including hypertension, arterial stiffness, vascular endothelial dysfunction, and autonomic dysfunction. These detriments persist despite pharmacological intervention. Habitual aerobic exercise can be protective of vascular health; however, the feasibility in patients with CKD is low due to numerous barriers to exercise. In this perspective we emphasize the need for novel and non-pharmacological strategies that can rescue vascular health and reduce the development of CVD in patients with CKD, explain the unique barriers to aerobic exercise in CKD, present a novel physical training intervention-high-resistance inspiratory muscle strength training (IMST) that addresses the barriers to exercise, and provide our opinion on why this lifestyle intervention may be particularly efficacious for patients with CKD.
慢性肾脏病（CKD）患者表现出血管加速老化，这导致心血管疾病（CVD）风险增加。CKD患者血管健康受损的特征是血管功能和结构改变，包括高血压、动脉僵硬、血管内皮功能障碍和自主神经功能障碍。尽管进行了药物干预，这些损害仍然存在。习惯性有氧运动可以保护血管健康；然而，由于运动存在诸多障碍，CKD患者进行运动的可行性较低。在这篇观点文章中，我们强调需要新的非药物策略来挽救CKD患者的血管健康并减少CVD的发生，解释CKD患者进行有氧运动的独特障碍，介绍一种新的体育训练干预措施——高阻力吸气肌力量训练（IMST），该训练可解决运动障碍，并阐述我们对于为何这种生活方式干预可能对CKD患者特别有效的看法。
