神经退行性疾病的成像技术：特定病理学检测的进展

Imaging technology for neurodegenerative diseases: progress toward detection of specific pathologies.

作者信息

Mathis Chester A, Klunk William E, Price Julie C, DeKosky Steven T

机构信息

Department of Neurology, University of Pittsburgh and Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, USA.

出版信息

Arch Neurol. 2005 Feb;62(2):196-200. doi: 10.1001/archneur.62.2.196.

DOI:10.1001/archneur.62.2.196

PMID:15710847

Abstract

Advances in neuroimaging over the past 2 decades are products of breakthroughs in imaging technology, developments of more powerful computers and image-processing software, and expanding knowledge in basic and clinical neuroscience. In addition to the insights into normal brain structure and function that such methods provide and the information that can be gained from disease-related changes in structure and function, the promise of achieving diagnostic specificity through neuroimaging lies with the potential identification of pathognomonic proteins. Recent advances in imaging beta-amyloid plaques, one of the hallmarks of Alzheimer disease, offer such a technological breakthrough and the possibility for more efficient assessment of antiamyloid interventions as well as specific noninvasive diagnostic capabilities.

摘要

过去20年里神经成像技术的进步得益于成像技术的突破、功能更强大的计算机和图像处理软件的发展，以及基础和临床神经科学知识的不断扩充。这些方法不仅能深入了解正常大脑的结构和功能，还能从与疾病相关的结构和功能变化中获取信息，而通过神经成像实现诊断特异性的希望在于潜在的特征性蛋白质识别。成像β淀粉样斑块（阿尔茨海默病的标志性特征之一）的最新进展带来了这样一项技术突破，为更有效地评估抗淀粉样蛋白干预措施以及实现特定的非侵入性诊断能力提供了可能。