血液系统疾病免疫功能低下患者长期使用伏立康唑后发生接合菌病：需予以关注。
Zygomycosis after prolonged use of voriconazole in immunocompromised patients with hematologic disease: attention required.
作者信息
Vigouroux Stéphane, Morin Odile, Moreau Philippe, Méchinaud Françoise, Morineau Nadine, Mahé Béatrice, Chevallier Patrice, Guillaume Thierry, Dubruille Viviane, Harousseau Jean-Luc, Milpied Noël
机构信息
Service d'Hematologie Clinique, CHU Hotel Dieu, Nantes, France.
出版信息
Clin Infect Dis. 2005 Feb 15;40(4):e35-7. doi: 10.1086/427752. Epub 2005 Jan 25.
We describe 4 cases of zygomycosis that occurred after prolonged use of voriconazole in severely immunocompromised patients with hematologic disease. An invasive infection was present in 3 patients who died soon after the diagnosis at 12, 13, and 45 days. Physicians should be mindful of this potential risk after treatment with voriconazole.
我们描述了4例在患有血液系统疾病的严重免疫功能低下患者中长期使用伏立康唑后发生的接合菌病病例。3例患者存在侵袭性感染，诊断后12天、13天和45天很快死亡。医生在使用伏立康唑治疗后应注意这种潜在风险。
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