González A, del Palacio A, Cuétara M S, Gómez C, Carabias E, Malo Q
Servicio de Microbiología, Hospital Universitario 12 de Octubre, Madrid.
Enferm Infecc Microbiol Clin. 1996 Apr;14(4):233-9.
Zygomycosis (mucormycosis or phycomycosis) is the infection caused by zygomycetes (non partitioned mycelial fungi, usually saprophytes). All cases of zygomycosis diagnosed in the Hospital 12 de Octubre in Madrid, Spain, from 1976 to 1994 were reviewed.
The underlying diseases of the patients, the factors favoring infection (alteration of the cutaneous barrier and administration of antimicrobians and corticosteroids) and the possible nosocomial origin of infection were analyzed.
Over this period of time, 16 cases of zygomycosis were diagnosed with different clinical forms depending on the route of entry (rhino-orbital-cerebral, cutaneous or disseminated). The species isolated were Rhizopus oryzae, Rhizomucor pusillus, Absidia corymbifera and Rhizopus stolonifer. The species could not be determined in two cases.
The diagnosis of zygomycosis should be based on a combined histological and microbiological study which allows both, differentiation between colonization and infection and isolation of the implicated species. Treatment is that of the underlying diseases, extensive surgical resection and amphotericin B.
接合菌病（毛霉病或藻菌病）是由接合菌（无隔膜菌丝真菌，通常为腐生菌）引起的感染。对1976年至1994年在西班牙马德里10月12日医院诊断的所有接合菌病病例进行了回顾。
分析了患者的基础疾病、有利于感染的因素（皮肤屏障改变以及使用抗菌药物和皮质类固醇）以及感染可能的医院内源性来源。
在此期间，诊断出16例接合菌病，根据感染途径（鼻眶脑型、皮肤型或播散型）有不同的临床形式。分离出的菌种有米根霉、少根根霉、伞枝犁头霉和匍枝根霉。2例无法确定菌种。
接合菌病的诊断应基于组织学和微生物学的联合研究，这既能区分定植和感染，又能分离出相关菌种。治疗方法是治疗基础疾病、广泛手术切除和使用两性霉素B。
