Schranz V, Gráf F
Third Department of Medicine, Semmelweis University Medical School, Budapest, Hungary.
Ann Hematol. 1992 Mar;64(3):140-5. doi: 10.1007/BF01697401.
Receptors for the Fc part of IgG (Fc gamma R) are expressed in three forms on peripheral blood lymphocytes. The presence of the releasable form (Fc gamma R(REL.)) as well as of the two nonreleasable forms with lower (Fc gamma R(LOW)) and higher (Fc gamma R(HIGH)) cellular avidity was correlated with survival in 63 patients with B-cell chronic lymphocytic leukemia (B-CLL). High percentage of cells with Fc gamma R(LOW) as well as high "absolute" number of cells carrying the two nonreleasable forms of Fc gamma R were connected to unfavorable prognosis. Combining these three parameters, an Fc gamma R constellation was defined which pointed to a favorable prognosis (in 24 patients) when all three parameters were low, but detected short survivors when all three data were high (in 14 patients). The Fc gamma R constellation was capable of identifying patients with better or worse prognosis within groups that were homogeneous regarding some other known prognostic factors. Fc gamma R constellation as a prognostic factor was shown to be independent of age, sex, and Rai and Binet stages, but it was found to be connected with the total tumor mass score (TTM). The three forms of Fc gamma R on B cells might reflect stages of B-cell activation. Differences in Fc gamma R constellations between patients with B-CLL would thus correspond to differently activated B-cell clones with variable prognosis.
免疫球蛋白G（IgG）Fc段受体（FcγR）在外周血淋巴细胞上以三种形式表达。可释放形式（FcγR(REL.)）以及两种细胞亲和力较低（FcγR(LOW)）和较高（FcγR(HIGH)）的不可释放形式的存在，与63例B细胞慢性淋巴细胞白血病（B-CLL）患者的生存期相关。FcγR(LOW)细胞比例高以及携带两种不可释放形式FcγR的细胞“绝对”数量多与不良预后相关。综合这三个参数，定义了一种FcγR组合模式，当所有三个参数都低时提示预后良好（24例患者），而当所有三个数据都高时则提示生存期短（14例患者）。FcγR组合模式能够在一些其他已知预后因素相同的组内识别预后较好或较差的患者。FcγR组合模式作为一种预后因素，被证明独立于年龄、性别、Rai分期和Binet分期，但发现它与肿瘤总质量评分（TTM）相关。B细胞上的三种FcγR形式可能反映了B细胞活化的阶段。因此，B-CLL患者之间FcγR组合模式的差异将对应于具有不同预后的不同活化B细胞克隆。
