O'Malley B P, Anderson I, Rosenthal F D
Br J Dermatol. 1979 Jun;100(6):703-5. doi: 10.1111/j.1365-2133.1979.tb08076.x.
An 18-year-old West Indian male presented with severe sternal pain and an exacerbation of facial acne. Radiographs of the sternum revealed several lytic lesions which appeared as hot areas on successive technetium bone scans. Painful areas over the right iliac crest and left greater trochanter likewise appeared as transient hot areas on successive scans. Histology of affected bone revealed reactive changes only. High dose prednisolone provided rapid alleviation of pain, which recurred on reducing the dose to less than 10 mg daily. Auto-immune complex disease has been considered the most likely aetiological mechanism of systemic acne (acne fulminans), but lytic lesions of bone have never previously been reported in auto-immune disorders.
一名18岁的西印度男性出现严重的胸骨疼痛和面部痤疮加重。胸骨X线片显示有几处溶骨性病变，在连续的锝骨扫描中表现为热点。右髂嵴和左大转子处的疼痛区域在连续扫描中同样表现为短暂的热点。受累骨骼的组织学检查仅显示反应性改变。高剂量泼尼松龙可迅速缓解疼痛，但当剂量减至每日低于10毫克时疼痛复发。自身免疫性复合病被认为是系统性痤疮（暴发性痤疮）最可能的病因机制，但自身免疫性疾病中此前从未有过骨溶骨性病变的报道。
