Denenberg V H, Sherman G F, Rosen G D, Morrison L, Behan P O, Galaburda A M
Biobehavioral Sciences Graduate Degree Program, University of Connecticut, Storrs 06269-4154.
Brain Behav Immun. 1992 Mar;6(1):40-9. doi: 10.1016/0889-1591(92)90058-v.
Since the NZB and BXSB autoimmune mouse strains have cortical ectopias and associated behavioral changes, mice from the MRL/l (MRL/Mp lpr/lpr) autoimmune strain were given a series of behavioral tests followed by anatomical analyses of their brains and immune assays of plasma. No cortical ectopias were found, but this strain was discovered to have a high incidence of hydrocephalus: 46% had severe dilatation of the lateral and third ventricles, 30% had moderate dilatation, and 24% had minimal or no enlargement of the ventricles (total N = 57). Those mice in the severe hydrocephalus group were poorer in a nonspatial discrimination learning task, had less paw asymmetry, and were less active in a swimming task. No association was found between degree of hydrocephalus and any immune parameter.
由于新西兰黑鼠（NZB）和BXSB自身免疫小鼠品系存在皮质异位及相关行为变化，因此对MRL/l（MRL/Mp lpr/lpr）自身免疫品系的小鼠进行了一系列行为测试，随后对其大脑进行解剖分析并对血浆进行免疫检测。未发现皮质异位，但发现该品系脑积水发生率很高：46%的小鼠侧脑室和第三脑室严重扩张，30%的小鼠中度扩张，24%的小鼠脑室轻度扩张或无扩张（总数N = 57）。重度脑积水组的小鼠在非空间辨别学习任务中表现较差，爪不对称性较小，在游泳任务中活动较少。未发现脑积水程度与任何免疫参数之间存在关联。
