Denenberg V H, Sherman G F, Morrison L, Schrott L M, Waters N S, Rosen G D, Behan P O, Galaburda A M
Biobehavioral Sciences Graduate Degree Program, University of Connecticut, Storrs 06269-4154.
Brain Res. 1992 Feb 7;571(2):323-9. doi: 10.1016/0006-8993(92)90671-u.
In a previous study, in which fertilized DBA ova were transferred into an autoimmune female, and NZB ova were transferred into a non-autoimmune female, we found that (1) the maternal environment affected the degree of autoimmunity, (2) the incidence of cortical ectopias was not affected by the maternal environment (3) DBA and NZB females had greater paw asymmetry if reared in an autoimmune uterus, and (4) avoidance learning scores were inversely related to degree of autoimmunity. In the present experiment, reciprocal crosses of DBA and BXSB mice were studied to confirm and extend the original findings. DB mice (DBA female x BXSB male) had greater immune activity than the BD animals, had poorer avoidance learning, but were better on black-white discrimination learning and the Lashley III maze. The BD mice had greater paw asymmetry. Only one of 38 animals had a cortical ectopia. The results lead to the following conclusions: (1) there is an inverse relationship between amount of immune activity and active avoidance learning; (2) some uterine factor in autoimmune mice causes females to have greater paw asymmetry; (3) cortical ectopias are under genetic control; and (4) the lesser immune activity of the BD mice suggests that they developed a suppressor system following early exposure to autoimmunity in the uterine/maternal environment.
在之前的一项研究中，我们将受精的DBA卵子移植到一只自身免疫性雌性小鼠体内，将NZB卵子移植到一只非自身免疫性雌性小鼠体内，结果发现：（1）母体环境影响自身免疫程度；（2）皮质异位的发生率不受母体环境影响；（3）如果在自身免疫性子宫内饲养，DBA和NZB雌性小鼠的爪不对称性更大；（4）回避学习得分与自身免疫程度呈负相关。在本实验中，对DBA和BXSB小鼠进行了正反交研究，以证实并扩展最初的发现。DB小鼠（DBA雌性×BXSB雄性）的免疫活性比BD小鼠更强，回避学习能力较差，但在黑白辨别学习和拉什利Ⅲ型迷宫实验中表现更好。BD小鼠的爪不对称性更大。38只动物中只有1只出现皮质异位。结果得出以下结论：（1）免疫活性量与主动回避学习之间存在负相关；（2）自身免疫性小鼠体内的某些子宫因素导致雌性小鼠爪不对称性更大；（3）皮质异位受基因控制；（4）BD小鼠较低的免疫活性表明，它们在子宫/母体环境中早期接触自身免疫后，发育出了一种抑制系统。
